[domweek] DOM Week, June 10-14, 2024

[Department of Medicine weekly newsletter via domweek]

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DOM Week
June 7, 2024
News, information, and events of interest from the Department of Medicine <http://bit.ly/1TemKEY>

(If you have items for DOM week, please email amyf at uw.edu<mailto:amyf at uw.edu>)


Awards
[cid:image002.jpg at 01DAB8F0.523F8F90]Evans Awards
Congratulations to the 2024 Evans Award recipients: Student Lili Szabo and residents Monica Soni and Ayman Youssef.

The Robert S. Evans Awards<https://bit.ly/4aOgBhL> are presented each year to the second-year medicine resident(s) and the graduating student(s) in medicine who most clearly reflect the qualities of warmth, understanding, and concern for the needs of others exemplified by and expressed through the life of Dr. Robert Evans, who was chief of medicine at Seattle VA Medical Center for many years.


DEI news
New Bias Navigators
[cid:image004.png at 01DAB8F0.523F8F90]We would like to introduce three new navigators to our Bias Navigator Program: Leila Armas-Valencia, program operations specialist (Pulmonary, Critical Care and Sleep Medicine), Andréa Campbell, assistant to the directors (Internal Medicine Residency Program) and Charlie Taylor, human resources manager (Hematology and Oncology). These three join Lori Joubert and Dr. Daniel Cabrera to comprise our Bias Navigator team.

Our Navigators are trained individuals dedicated to providing safe, confidential support to help guide Department of Medicine faculty, staff and trainees through bias incidents they may have experienced in the workplace. Navigators can provide a safe space to express concerns, help to navigate through the resources and options available, and provide conflict resolution coaching.

Learn more about our Bias Navigators on our website<https://bit.ly/3jS5u2E>.

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Bystander intervention training: Scenario testers needed
The Office of Healthcare Equity, in partnership with colleagues in Emergency Medicine, is developing on-the-fly bystander intervention training to be introduced to leaders of clinical rounds. They are looking for people with lived experiences with respect to scenarios that address anti-Black, trans, gay, Latina, Indigenous, and Muslim bias. They would like testers to provide feedback on the scenarios as well as the process. If interested, please sign up for a time slot<https://bit.ly/3Va58TN>. Contact Malavika Arun<mailto:marun17 at uw.edu> with questions.


Faculty news
[cid:image006.jpg at 01DAB8F0.523F8F90]Dr. Anita Chopra, clinical assistant professor (General Internal Medicine) was invited to the 2024 U.S. Healthcare Leadership Summit<https://bit.ly/3VES7TX> focused on Long COVID rehabilitation. She represented the American College of Physicians (ACP) and the UW Long COVID Clinic. Created to advance the collaborative care of this health condition, this invitation-only event was hosted the American Physical Therapy Association (APTA) and the Office of Long COVID Research and Practice, U.S. Department of Health & Human Services (HHS).


Staff news
[Andrea Campbell]Staff spotlight: Andréa Campbell
Our latest staff spotlight is on Andréa Campbell, assist to the directors for our Internal Medicine Residency Program.

Learn more about her on our news site<https://bit.ly/3Xaast7>.


Education news
New Residency Program Directors
The Seattle IM Residency Program will welcome two new program directors on July 1:

[cid:image010.jpg at 01DAB8F0.523F8F90]Dr. Rosemary Adamson, associate professor (Pulmonary, Critical Care, and Sleep Medicine) will be associate program director for teaching skills. Adamson is pulmonary and critical care physician at the VA Puget Sound. An inpatient chief resident at NYU before coming to UW for fellowship, she is a graduate of the UW Teaching Scholars Program and has a certificate in Medical Education Research from the AAMC.


[cid:image012.jpg at 01DAB8F0.523F8F90]Dr. Michael Lenaeus, assistant professor (General Internal Medicine) will be associate program director for research and scholarship. Lenaeus is a physician in the hospital medicine group at UWMC-Montlake and was an inpatient chief resident at Montlake in 2013-14. He is an outstanding teacher and clinician who also has a PhD and does basic science research in cardiology and cardiovascular pharmacology.



Research news
Cystic Fibrosis Research Development Program
[Drs. Pradeep Singh and Ajai Dandekar]Drs. Pradeep Singh, professor and Ajai Dandekar, associate professor (Pulmonary, Critical Care and Sleep Medicine) have been awarded a $3.6 million 4-year grant from the Cystic Fibrosis Foundation to support laboratory-based research on cystic fibrosis (CF).

Learn more on our news site<https://bit.ly/3VfRrCM>.
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Immune-system signaler also appears to cause kidney injury
[cid:image016.jpg at 01DAB8F0.523F8F90]Interferons, part of the body's immune system, appear to cause kidney damage most likely to affect Black people, newly published research suggests<https://bit.ly/3V8wh9D>. The investigators also found that drugs approved for other conditions can thwart this detrimental side effect of interferons.

Researchers examined the activity of a gene that responds to interferon and is also associated with kidney disease. This gene, called APOL1, has mutations that are common among people with African ancestry.

"We saw in the organoids that interferon caused APOL1 levels of expression to go up. But we also noticed that the interferon itself was associated with an inflammatory form of cell death in blood vessels' endothelial cells - even in the context of normal levels of APOL1," said Dr. Benjamin Freedman, associate professor (Nephrology), the study's senior author (lead author is Dr. Benjamin Juliar, postdoctoral scholar).

Read the full story from UW Medicine Newsroom<https://bit.ly/45irbfS>.

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[cid:image018.jpg at 01DAB8F0.523F8F90]Dr. May Reed, associate professor (Gerontology and Geriatric Medicine) is PI and has been awarded a $2.6 million NIH/NIA R01 titled: "Collagen IV and Amyloid Beta Interactions in Alzheimer's Disease." DOM members on the grant include William Banks (Co-I) and Michelle Erickson (VA PI subaward).

Dr. Reed has also been appointed MPI for the TRIAD R01 (Test of Rapamycin in Aging Dogs) as well as PI for Core A and Project 1 of the overall Dog Aging Project U19. Resubmission Grants to NIA are presently under review for both the TRIAD R01 and The DAP U19, but in the meantime the projects have garnered nearly 4 million in private donations.

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[cid:image020.jpg at 01DAB8F0.523F8F90]Dr. Sarah Holton, acting instructor (Pulmonary, Critical Care and Sleep Medicine) received funding from the Parker B. Francis Fellowship Program for her project: "The role of CD163+ monocytes and macrophages in Progressive Pulmonary Fibrosis." Dr. Carmen Mikacenic is her mentor on this award. The Parker B. Francis Fellowship provides research support to clinical and basic scientists embarking on careers in clinical, laboratory or translational science related to Pulmonary, Critical Care and Sleep Medicine.

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[cid:image022.jpg at 01DAB8F0.523F8F90]Dr. Neha Sathe, acting instructor (Pulmonary, Critical Care and Sleep Medicine) received funding from the Firland Foundation for her project: "Understanding effects of fluid resuscitation among patients hospitalized with community acquired pneumonia." The Firland Foundation provides grants directed toward the funding of research and treatment of tuberculosis and other respiratory diseases, to build regional capacity, and to support advocacy for the control and elimination of TB.



Well-being survey
Please take the 2024 UW Medicine Well-Being Survey<https://bit.ly/3mb1ic0> to help us evaluate the current state of well-being and professional fulfillment of our members and help us build a workplace that supports the well-being of all employees. The survey will be open until June 25.


Recent publications
Dr. Michael Boeckh, professor, is lead author, and Dr. Joshua Hill, associate professor (Allergy and Infectious Diseases) is senior author of "How Immunocompromised Hosts Were Left Behind in the Quest to Control the Covid-19 Pandemic<https://bit.ly/3VdIYQL>" in Clinical Infectious Diseases. DOM co-authors are Steven Pergam, Ajit Limaye, and Lawrence Corey.

Dr. Karin Bornfeldt, professor (Metabolism, Endocrinology and Nutrition) is senior author of "Imbalance of APOB Lipoproteins and Large HDL in Type 1 Diabetes Drives Atherosclerosis<https://bit.ly/4efHOwP>" in Circulation Research. DOM co-authors are Farah Kramer, Masami Shimizu-Albergine, Jenny Kanter, Baohai Shao, Jay Heinecke, and Tomas Vaisar.

Dr. Megan Files, postdoctoral scholar, is lead author, and Dr. Chetan Seshadri, associate professor (Allergy and Infectious Diseases) is senior author of "The kinetics and durability of antibody and T-cell responses to SARS-CoV-2 in children<https://bit.ly/3x2Ro5n>" in the Journal of Infectious Diseases.

Dr. James Floyd, associate professor (General Internal Medicine) is senior author of "Finding uncoded anaphylaxis in electronic health records to estimate the sensitivity of ICD10 codes<https://bit.ly/3X9fS7K>" in the American Journal of Epidemiology. DOM co-author is Maralyssa Bann. Dr. Floyd is also co-author of "High Throughput Plasma Proteomics and Risk of Heart Failure and Frailty in Late Life<https://bit.ly/4bIKelS>" in JAMA Cardiology.

Dr. Jason Goldman, clinical assistant professor (Allergy and Infectious Diseases) is co-author of "Integrated Antigenic and Nucleic Acid Detection in Single Virions and Extracellular Vesicles with Viral Content<https://pubmed.ncbi.nlm.nih.gov/38820600/>" in Advanced Healthcare Materials, and "A simplified pneumonia severity index (PSI) for clinical outcome prediction in COVID-19<https://pubmed.ncbi.nlm.nih.gov/38820600/>" in PLoS One.

Dr. Geoffrey Hill, professor (Hematology and Oncology) is senior author of "Calcineurin inhibition rescues alloantigen-specific central memory T cell subsets that promote chronic GVHD<https://bit.ly/3Rlwo0v>" in JCI.

Dr. Sara Hurvitz, professor and head (Hematology and Oncology) is co-author of "Trastuzumab deruxtecan versus trastuzumab emtansine in HER2-positive metastatic breast cancer: long-term survival analysis of the DESTINY-Breast03 trial<https://go.nature.com/3VbWJ2c>" in Nature Medicine.

Drs. Janine Maenza, clinical professor, Ann Collier, professor emeritus, and James Mullins, professor (Allergy and Infectious Diseases) are co-authors of "Antigen specificities and proviral integration sites differ in HIV-infected cells by timing of antiretroviral treatment initiation<https://bit.ly/4aR4SyQ>" in the Journal of Clinical Investigation.

Dr. Ila Nimgaonkar, R2, is lead author, and Dr. Joshua Hill, associate professor (Allergy and Infectious Diseases) is senior author of "Acute Endothelial Complications Post-Allogeneic Hematopoietic Cell Transplant in Patients with Pre-Cellular Therapy SARS-CoV-2 Infection<https://bit.ly/3Vxlc3B>" in Clinical Infectious Diseases. DOM co-author is Masumi Ueda Oshima.

Dr. Evan Yu, professor (Hematology and Oncology) is co-author of "Pembrolizumab for advanced urothelial carcinoma: exploratory ctDNA biomarker analyses of the KEYNOTE-361 phase 3 trial<https://go.nature.com/4ed98eX>" in Nature Medicine.



In the news
Dr. Bradley Anawalt, professor (General Internal Medicine) is quoted in "Science alone can't solve fairness debate on transgender athletes, says expert endocrinologist and UW professor<https://bit.ly/3yMja6A>" in the Spokesman-Review.

Dr. Connie Celum, professor (Allergy and Infectious Diseases) is quoted in "CDC endorses prophylactic antibiotics to reduce STIs in high-risk groups<https://bit.ly/3yXKfUk>" in STAT.

Dr. Christopher Damman, clinical associate professor (Gastroenterology) is quoted in "How eating less salt can improve microbiome health<https://wapo.st/3RdDmVt>" in the Washington Post.

Dr. Corinne Heinen, clinical professor (Allergy and Infectious Diseases) is quoted in "The Pride in Friendship: How to Build Queer Community<https://bit.ly/45974Rc>" in Right as Rain.

Dr. Vishesh Kapur, professor (Pulmonary, Critical Care and Sleep Medicine) is quoted in "How to Get Back to Sleep After Waking Up at Night<https://bit.ly/45d6m5c>" in Time.

Dr. Nicolae Leca, professor, and Glenda Roberts, director of external relations and patient engagement (Nephrology) are quoted in "A racially biased test miscalculated kidney health for Black patients<https://bit.ly/3Xh7m6v>" from KING 5 News.

Dr. Elizabeth Loggers, clinical associate professor (Hematology and Oncology) is quoted in "Palliative care for cancer patients is found to be as effective given virtually as in person<https://bit.ly/3V9Llnx>" in STAT.


Weekly Calendar, June 10-14, 2024
Our events calendar is posted on our website<https://medicine.uw.edu/news/trumba-calendar>.


Coming up
Research Fellows Orientation Course
Registration is now open<https://forms.office.com/r/Pv3cKnKidg> for our annual Department of Medicine Workshop: "Surviving and Thriving During the Research Years", a course covering skills necessary for academic success, such as grant & manuscript writing, mentorship, appointments & promotions, and breakout sessions on opportunities in industry or the public health & policy sector. The course is designed for fellows navigating their research path and is open to clinical and PhD fellows and early-stage faculty from all departments. There is no charge to attend this course. Aug. 19, 8:30am-3pm, Brotman Auditorium, South Lake Union. Please register for this course<https://forms.office.com/r/Pv3cKnKidg>. For more information please contact Ellen Schur (ellschur at uw.edu<mailto:ellschur at uw.edu>) or Nisha Bansal (nbansal at uw.edu<mailto:nbansal at uw.edu>).



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Amy Fields, Editor
amyf at uw.edu<mailto:amyf at uw.edu>


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