[domweek] DOM Week, July 1-5, 2024

[Department of Medicine weekly newsletter via domweek]

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DOM Week
June 28, 2024
News, information, and events of interest from the Department of Medicine <http://bit.ly/1TemKEY>

(If you have items for DOM week, please email amyf at uw.edu<mailto:amyf at uw.edu>)

Awards
[Drs. Heather Cheng and Evan Yu]Best Prostate Cancer Oncologists
Congratulations to Drs. Heather Cheng, associate professor, and Evan Yu, professor (Hematology and Oncology) who were listed in the first annual ranking of America's Best Prostate Cancer Oncologists by Newsweek and Statista.

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Outstanding Primary Palliative Care Education award
[Dr. David Carlbom]Dr. David Carlbom, associate professor (Pulmonary, Critical Care and Sleep Medicine) is the recipient of the 2024 Cambia Palliative Care Center of Excellence Award for Outstanding Primary Palliative Care Education. This regional award recognizes outstanding bedside teaching/modeling of palliative care skills, a commitment to DEI in teaching of palliative care skills, and outstanding modeling of empathy and compassion towards people with serious illness and their families.

Education news
2024 Distinguished CHEST Educator
[Dr. Başak Çoruh]Dr. Başak Çoruh, associate professor (Pulmonary, Critical Care and Sleep Medicine) has been recognized by the American College of Chest Physicians (CHEST) as a 2024 Distinguished CHEST Educator. This designation provides national-level recognition of excellence in continuing medical education through commitment, involvement, and leadership in CHEST education programs and activities.



Research news
Department of Medicine Research Dashboard
We are thrilled to announce the launch of the UW Department of Medicine Research Dashboard<https://bit.ly/3XDgkeD>, a powerful new tool designed to enhance our department's research efforts.

The dashboard provides a comprehensive visual representation of research grant proposals and awards submitted and obtained by faculty from 2016-2023. This data can be easily explored by individual faculty members, trainees, staff, divisions, or the entire department, offering valuable insights for:

*      Internal tracking of extramural grant applications and funding
*      Facilitating collaboration and supporting mentorship by enabling searches for grant proposals and awards by topic and methodology

To help navigate and maximize the utility of this new resource, we will be hosting office hours for data queries and assistance on July 15 and August 14, 12-1pm. In the meantime, please direct any questions to Michael Dudley<mailto:dudlem at medicine.washington.edu>.

We believe the Research Dashboard will be a transformative tool for the department's research endeavors. We encourage you to explore the dashboard and discover the valuable insights it can provide.

(Please note: VPN is required to access the dashboard for remote/non-UW internet connections. Answers to dashboard FAQs may be found on our intranet<https://bit.ly/3zl4ko5>.)

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[cid:image009.jpg at 01DAC976.63528FD0]Kuni Foundation Grants
Congratulations to the following DOM members who received grants from the Kuni Foundation to propel adult oncology and cancer vaccine research.

Adult oncology research


  *   Drs. Shailender Bhatia, professor (Hematology and Oncology) and collaborators Lisa Tachiki, assistant professor, and Manoj Menon, associate professor (Hematology and Oncology) are testing a markedly lower-dose plus reduced-frequency strategy of the immunotherapy drug nivolumab, to potentially make the drug available to patients who would otherwise not have access to the drug.


  *   Dr. David Hockenbery, professor (Gastroenterology) and collaborators are unraveling a marsupial medical mystery. They are studying Tasmainian devils in hopes of developing a therapy that could one day make tumors disappear.

Learn more from Hutch News<https://bit.ly/3xsR0gN>.

Cancer vaccine research


  *   Dr. Denise Cecil, research scientist (Hematology and Oncology) is developing a vaccine for ovarian cancer prevention. The vaccine will target proteins that are found at high levels in STIC and ovarian cancers, helping train the immune system to create an immune response to eliminate them.


  *   Dr. Mary (Nora) Disis, professor (Hematology and Oncology) is collaborating with Dr. Miqin Zhang (UW Institute of Nano-engineered Systems) to develop an advanced nanovaccine to combat breast cancer.


  *   Dr. Shaveta Vinayak, associate professor (Hematology and Oncology) is addressing the unmet medical needs of patients with PD-L1-negative triple-negative metastatic breast cancer. Vinayak and the CVI team will conduct a clinical trial in patients with PD-L1 negative metastatic TNBC with the STEMVAC vaccine.

Learn more from the Cancer Vaccine Institute<https://bit.ly/3XE85yV>.

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Study crystallizes distinct kidney benefits of common drug
[Dr. Katherine Tuttle]In May, researchers announced the landmark finding<https://bit.ly/4axCOAA> that semaglutide, the compound in the common diabetes and weight-loss drugs Ozempic and Wegovy, also effectively reduced risks of kidney and heart complications and death in people with chronic kidney disease and type 2 diabetes.

It was "the biggest win yet of a completed trial for kidney disease," said study coauthor Dr. Katherine Tuttle, clinical professor (Nephrology).

This week, Tuttle and her colleagues published a related finding<https://go.nature.com/3VCTzVw> that shows semaglutide's benefit is distinct from that of another class of drugs shown to be highly kidney-protective, sodium-glucose transport protein 2 (SGLT2) inhibitors, including the medications Jardiance, Farxiga and Invokana.

Read the full story from UW Medicine Newsroom<https://bit.ly/3L0K91g>.

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Using AI for Tuberculosis Classification Using Wearable Data
The Population Health Initiative announced the award of five, $100,000 artificial intelligence-focused pilot grants to support interdisciplinary teams of University of Washington researchers to develop preliminary data or proof-of-concept needed to pursue follow-on funding to scale their respective efforts.

[Drs. Thomas Hawn and Dr. David Horne]Researchers from DOM - Drs. Thomas Hawn, professor (Allergy and Infectious Diseases) and David Horne, associate professor (Pulmonary, Critical Care and Sleep Medicine) - and Dr. Shwetak Patel (Allen School of Computer Science & Engineering) received a grant for a pilot study that aims to use wearable sensors to classify TB infection based on cough characteristics in real-world settings.

The primary aim will be to collect continuous data with lab test ground truth to create an ML model diagnosing TB infection that is robust across situationally diverse conditions. Secondarily they will explore the use of biometrics from Fitbit data, and the use of generative AI as ways to create a more robust classifier.

Learn more on our news site<https://bit.ly/3zkWpXP>.

Recent publications
Dr. Jason Dominitz, professor (Gastroenterology) is co-author of "Comparative Effectiveness and Cost-Effectiveness of Colorectal Cancer Screening With Blood-Based Biomarkers (Liquid Biopsy) vs Fecal Tests or Colonoscopy<https://bit.ly/3xzbm86>" in Gastroenterology.

Drs. Jason Goldman, clinical assistant professor (Allergy and Infectious Diseases) and Katherine Tuttle, clinical professor (Nephrology) are co-authors of "Efficacy and Safety of Remdesivir in People With Impaired Kidney Function Hospitalized for COVID-19 Pneumonia: A Randomized Clinical Trial<https://bit.ly/3VFxzt7>" in Clinical Infectious Diseases.

Dr. Livia Hegerova, clinical assistant professor (Hematology and Oncology) is co-author of "JAK inhibition enhances checkpoint blockade immunotherapy in patients with Hodgkin lymphoma<https://bit.ly/4bsbBzA>" in Science.

Dr. Reena Mehra, professor and head (Pulmonary, Critical Care and Sleep Medicine) is senior author of "Adverse Cardiovascular Outcomes in Patients with Obstructive Sleep Apnea and Obesity: Metabolic Surgery versus Usual Care<https://bit.ly/45M27On>" in the Journal of the American College of Cardiology.

Dr. Babak Nazer, associate professor (Cardiology) is co-author of "A Clinical Diagnostic Test for Calcium Release Deficiency Syndrome<https://bit.ly/4cGFAoG>" in JAMA.

Dr. Tara Reid, acting instructor, is lead author, and Dr. David Koelle, professor (Allergy and Infectious Diseases) is senior author of "Treponema pallidum Periplasmic and Membrane Proteins Are Recognized by Circulating and Skin CD4+ T Cells<https://bit.ly/4eJIEBU>" in the Journal of Infectious Diseases. DOM co-authors are Charmie Godornes, Victoria Campbell, Kerry Laing, Lauren Tantalo, Thepthara Pholsena, Lorenzo Giacani, Caroline Cameron, Julia Dombrowski, and Anna Wald.

Dr. Yutaka Tomizawa, clinical associate professor (Gastroenterology) is co-author of "Hybrid versus Conventional Colorectal Endoscopic Submucosal Dissection: A Multi-Center Randomized Controlled Trial (SHORT-ESD)<https://bit.ly/3VKEwJz>" in the American Journal of Gastroenterology.

Dr. Evan Yu, professor (Hematology and Oncology) is co-author of "Restaging With Prostate-Specific Membrane Antigen Imaging in Metastatic Castration-Resistant Prostate Cancer: When Seeing More Is Detrimental to Care<https://bit.ly/3x7flbq>" in the Journal of Clinical Oncology.

Dr. Danniel Zamora, acting assistant professor, is lead author, and Dr. Michael Boeckh, professor (Allergy and Infectious Diseases) is senior author of "CMV Reactivation during Pre-Transplantation Evaluation: A Novel Risk Factor for Post-Transplantation CMV Reactivation<https://bit.ly/3XIew48>" in Blood Advances. DOM co-authors are Melinda Biernacki, Masumi Ueda Oshima, Margaret Green, Leona Holmberg, Geoffrey Hill, and Joshua Hill.

In the news
Drs. Rachel Bender Ignacio, assistant professor, and Matthew Golden, professor (Allergy and Infectious Diseases) are quoted in "The Future of HIV Treatment Is Injectable<https://bit.ly/45ALo0z>" in the Stranger.

Dr. Larry Corey, professor (Allergy and Infectious Diseases) is quoted in "AIDS crisis from 1980s to today: How Seattle responded with hope, healing<https://bit.ly/3W1HwT2>" in the Seattle Times.

Dr. Heidi Crane, professor (Allergy and Infectious Diseases) talked to NPR Weekend Edition in "People with HIV are aging and the challenges are piling up<https://n.pr/4cgm4PQ>."

Dr. Scott Hagan, assistant professor (General Internal Medicine) is quoted in "Sanders targets 'unacceptable' price of weight-loss drugs Ozempic and Wegovy<https://bit.ly/4cDjAuA>" in the Guardian.

Dr. Irl Hirsch, professor (Metabolism, Endocrinology and Nutrition) is quoted in "Inhaled Insulin Plus Degludec an Option for Type 1 Diabetes<https://wb.md/4czJn78>" in Medscape.

Dr. Joel Kaufman, professor (General Internal Medicine) is quoted in "Lab experiment shows exactly how heat waves can put hearts into 'oxygen debt'<https://bit.ly/3xyZnr6>" in STAT.

Dr. Brad Rolf, assistant teaching professor (Medical Genetics) is featured in the recent Huddle article "LGBTQ+ UW Medicine Employees: On Being Our Authentic Selves.<https://bit.ly/3RI3ZBV>"

Dr. Gregory Roth, associate professor (Cardiology) is quoted in "Burden of CVD Still High in UK Despite Prevention Efforts Over 20 Years<https://bit.ly/3W1Ur7q>" in TCTMD.


Weekly Calendar, July 1-5, 2024
Our events calendar is posted on our website<https://medicine.uw.edu/news/trumba-calendar>.

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Amy Fields, Editor
amyf at uw.edu<mailto:amyf at uw.edu>

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