[domweek] DOM Week, July 22-26, 2024

[Department of Medicine weekly newsletter via domweek]

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DOM Week
July 19, 2024
News, information, and events of interest from the Department of Medicine <http://bit.ly/1TemKEY>

(If you have items for DOM week, please email amyf at uw.edu<mailto:amyf at uw.edu>)


Staff news
[Pankhuri Gupta]Staff spotlight: Pankhuri Gupta
Our latest staff spotlight is on Pankhuri Gupta, genetics counselor (Medical Genetics).

Learn more about her on our news site<https://bit.ly/3xON8Hb>.


Faculty news
[Dr. Nazem Akoum]Endowed Professorship in Arrhythmia Research
Dr. Nazem Akoum, professor (Cardiology) is the inaugural holder of the Graham and Brenda Siddall Endowed Professorship in Arrhythmia Research. Dr. Akoum is an expert and national authority on the genesis, mechanisms, and treatment of atrial fibrillation. He directs the Atrial Fibrillation Program and the Clinical Cardiac Electrophysiology Fellowship Program and is section head of Cardiac Electrophysiology.
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[Dr. Thomas Payne]Faculty spotlight: Thomas Payne
Our latest faculty spotlight is on Dr. Thomas Payne, professor emeritus (General Internal Medicine), who recently retired from the University of Washington after over 30 years of service.

Learn more about him on our news site<https://bit.ly/3SdaBIJ>.


Research news
New gene therapy for muscular dystrophy offers hope
[Dr. Jeffrey Chamberlain]A new gene therapy treatment for Duchenne muscular dystrophy (DMD) shows promise of not only arresting the decline of the muscles of those affected by this inherited genetic disease, but perhaps, in the future, repairing those muscles. The results were published this week in Nature<https://go.nature.com/4cVTByO>.

Senior author Dr. Jeffrey Chamberlain, professor (Medical Genetics) has worked his entire career on finding therapeutics and seeking a cure for muscular dystrophy.
What has stymied researchers in the past is the gene which needs to be fixed "is the largest gene in nature," Chamberlain noted. Up until now, there was no way to deliver the needed protein fixes into the muscles and their genes. "Think of having a king-sized bed delivered that you can't get through your door," he said.

Read the full story from UW Medicine Newsroom<https://bit.ly/4faLfoL>.

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The future of immunotherapy
[Dr. Mazyar Shadman]Dr. Mazyar Shadman, associate professor (Hematology and Oncology) is a blood cancer expert whose research focuses on developing novel therapeutic agents such as targeted therapy and immunotherapy for lymphoid malignancies. He runs clinical trials that harness these novel agents to treat blood cancers, especially chronic lymphocytic leukemia and lymphoma. Shadman says immunotherapy is "a game-changer for our patients" and that immunotherapy services are expanding to meet demand.

Shadman is the new medical director of the Bezos Family Immunotherapy Clinic, taking the helm from Dr. David Maloney, who retired after serving as the clinic's first medical director since 2016 when the clinic opened.

Shadman discusses his vision for the future of immunotherapy in a Q&A from Hutch News<https://bit.ly/3Wtz13i>. He is also co-chairing the 2024 Seattle Cellular Therapy Summit<https://bit.ly/4cNLNPQ> on Aug. 16-17.

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[Dr. Tomas Mustelin]Dr. Tomas Mustelin, professor and head (Rheumatology) has received an R01 for his project "Upstream drivers of type I interferons in lupus." This multi-PI project aims to fill an important knowledge gap: what are the upstream pathways that drive the chronic production of type I interferons (IFN-Is) in immune cells and in skin in systemic lupus erythematosus (SLE)? Elucidating these pathways would enable the development of more effective and potentially much safer new treatments for this disease.

Dr. Mustelin has also received an R21 for "Alternative splicing and expression of transposable elements in aging skeletal muscle" (DOM co-I is Dr. Rayan Najjar).

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[Dr. Lauren Pollack]Congratulations to Dr. Lauren Pollack, acting instructor (Pulmonary, Critical Care and Sleep Medicine) who is a 2024 American Academy of Hospice and Palliative Medicine Research Scholar<https://bit.ly/4da00q2>. This program aims to advance the scientific endeavors of new/early investigators (who have applied for or will shortly apply for a Career Development Award) whose goal is to become independent scientists actively involved in palliative care research.


Recent publications
Dr. Gregory Condos, acting instructor, is lead author, and Dr. James McCabe, professor (Cardiology) is senior author of "Hemodynamic Tolerance of TEER Device Extraction Followed by TMVR<https://bit.ly/4d5JuHS>" in JACC Cardiovascular Interventions. DOM co-authors are David Elison and Christine Chung.

Drs. Paul Cornia, professor, Michael Krug, clinical associate professor, and Meghna Shah, clinical assistant professor (General Internal Medicine) are co-authors of "Medications for alcohol-use disorder and follow-up after hospitalization for alcohol withdrawal: A multicenter study<https://bit.ly/3S9Pabt>" in the Journal of Hospital Medicine.

Dr. Benjamin Freedman, associate professor, and Thomas Vincent, research assistant (Nephrology) and Dr. Charles Murry, professor (Cardiology) are co-authors of "Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies<https://bit.ly/3Lw5nnQ>" in Cell.

Dr. Michael Krug, clinical associate professor, is lead author and Dr. William Weppner, associate professor (General Internal Medicine) is senior author of "The Impact of Changing From a 6+2 to a 3+1 Residency Block Schedule on Patient Access and Other Outcomes<https://bit.ly/46cIPC1>" in the Journal of Graduate Medical Education. DOM co-authors are Alicia Carrasco and Andrea Christopher.

Dr. Emily Liang, fellow (Hematology and Oncology) is co-author of "How I use next-generation sequencing-MRD to plan approach and prevent relapse after HCT for children and adults with ALL<https://bit.ly/4cZszXu>" in Blood.

Jenni Logue, program manager, and Dr. Helen Chu, professor (Allergy and Infectious Diseases) are co-authors of "Spike deep mutational scanning helps predict success of SARS-CoV-2 clades<https://go.nature.com/46eNALA>" in Nature.

Dr. Reena Mehra, professor and head (Pulmonary, Critical Care and Sleep Medicine) is senior author of "Novel Sleep Phenotypic Profiles Associated With Incident Atrial Fibrillation in a Large Clinical Cohort<https://bit.ly/3LrcDBv>" in JACC Clinical Electrophysiology.

Dr. Oliver McElvaney, fellow (Pulmonary, Critical Care and Sleep Medicine) is lead author of "International Medical Graduates and the Physician Workforce<https://bit.ly/3LruLem>" in JAMA.

Dr. Fatemeh Moadab, postdoctoral scholar, is lead author and Dr. Tomas Mustelin, professor and head (Rheumatology) is senior author of "Evidence of membranolytic targeting and intracellular citrullination in neutrophils isolated from patients with rheumatoid arthritis<https://go.nature.com/3y2OKgu>" in Scientific Reports. DOM co-authors are Xiaoxing Wang, Ethan Le, Tal Gazitt, Rayan Najjar, J. Lee Nelson, and Keith Elkon.

Dr. Amy Morris, associate professor (Pulmonary, Critical Care and Sleep Medicine) is senior author of "A Multidisciplinary Curriculum to Standardize Chest Procedures Training for Trainees in General Surgery, Emergency Medicine, and Critical Care<https://bit.ly/4dbNcjf>" in MedEdPORTAL.

Dr. Andrew Raikhel, assistant professor, is lead author and Dr. Jeffrey Redinger, assistant professor (General Internal Medicine) is senior author of "Through the Looking Glass: Comparing Hospitalists' and Internal Medicine Residents' Perceptions of Feedback<https://bit.ly/4f1eaLX>" in Cureus. DOM co-author is Gabrielle Berger.

Dr. Chetan Seshadri, professor (Allergy and Infectious Diseases) is senior author of "Specific CD4+ T cell phenotypes associate with bacterial control in people who 'resist' infection with Mycobacterium tuberculosis<https://go.nature.com/46ryq5P>" in Nature Immunology. DOM co-authors are Nathan Kieswetter, Krystle Yu, and Thomas Hawn.

Dr. Matthew Triplette, associate professor (Pulmonary, Critical Care and Sleep Medicine) is senior author of "Understanding determinants of lung cancer preventive care in at-risk urban American Indians and Alaska Natives: A mixed-methods study<https://bit.ly/3xYaTwo>" in Preventative Medicine Reports.

Dr. Katherine Tuttle, clinical professor (Nephrology) is co-author of "Selonsertib in Patients with Diabetic Kidney Disease: A Phase 2b Randomized Active Run-In Clinical Trial<https://bit.ly/3Y8UIHb>" in the Journal of the American Society of Nephrology.

Dr. Sakeneh Zraika, research professor (Metabolism, Endocrinology and Nutrition) is senior author of "Gut-specific Neprilysin Deletion Protects Against Fat-induced Insulin Secretory Dysfunction in Male Mice<https://bit.ly/3LsZisg>" in Endocrinology.


In the news
Dr. Jeffrey Chamberlain, professor (Medical Genetics) is quoted in "New gene therapy for muscular dystrophy offers hope<https://bit.ly/3YrTg31>" in Science Magazine.

Dr. Reena Mehra, professor and head (Pulmonary, Critical Care and Sleep Medicine) is quoted in "Constellations of Sleep Issues Can Point to Patients at Risk for AF<https://bit.ly/46d2hhT>" in tctmd.

Dr. Lauren Pollack, acting instructor (Pulmonary, Critical Care and Sleep Medicine) is quoted in "Coping With Seasonal Allergies and COPD<https://bit.ly/3zKZXTt>" in Every Day Health.


Weekly Calendar, July 22-26, 2024
Our events calendar is posted on our website<https://medicine.uw.edu/news/trumba-calendar>.


Coming up
Research Fellows Orientation Course
Registration is open for our annual Department of Medicine Workshop: "Surviving and Thriving During the Research Years<https://bit.ly/3S3jx3D>", a course covering skills necessary for academic success, such as grant & manuscript writing, mentorship, appointments & promotions, and breakout sessions on opportunities in industry or the public health & policy sector. The course is designed for fellows navigating their research path and is open to clinical and PhD fellows and early-stage faculty from all departments. There is no charge to attend this course. Aug. 19, 8:30am-3pm, Brotman Auditorium, South Lake Union. Please register for this course<https://forms.office.com/r/Pv3cKnKidg>. For more information please contact Ellen Schur (ellschur at uw.edu<mailto:ellschur at uw.edu>) or Nisha Bansal (nbansal at uw.edu<mailto:nbansal at uw.edu>).


________________________________

Amy Fields, Editor
amyf at uw.edu<mailto:amyf at uw.edu>


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