[domweek] DOM Week, April 18-22, 2022

[Department of Medicine weekly newsletter]

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DOM Week
April 15, 2022
News, information, and events of interest from the Department of Medicine <http://bit.ly/1TemKEY>

(If you have items for DOM week, please email amyf at uw.edu<mailto:amyf at uw.edu>)



Faculty news
[cid:image003.jpg at 01D850E9.569CD370]Dr. Philip Greenberg, professor (Medical Oncology) has been elected American Association for Cancer Research (AACR) President-Elect for 2022-2023. An internationally recognized pioneer in the field of cancer immunobiology, Greenberg has made groundbreaking contributions examining host T-cell responses to pathogenic viral infections.

His work has led to crucial insights into the understanding of the mechanisms by which T cells distinguish tumor cells from normal cells and has fueled the advancement of adoptive T-cell therapy approaches in various cancers, including leukemia. His research also showed that CD4-positive helper T cells work both collaboratively and independently of CD8-positive cytotoxic T cells to eradicate tumor cells. This work has since been applied to the development of treatments for late-stage melanoma and leukemia. Read the full news release from the AACR<https://bit.ly/3KwJbId>.

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[Head shot of Myla Morales-Tomas]Myla Morales-Tomas, teaching associate (Rheumatology) has been recognized as a change maker by the American College of Rheumatology. A rheumatology change maker is anyone in the field of rheumatology working to start or support an initiative or intervention, bring a program or idea to reality, or improve the quality of life of a group or community: A true leader, an inspired visionary, or front-line professional willing to do whatever it takes to keep things going.
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Women Faculty Leadership Series
Sponsored by the Dean's Standing Committee on Women in Medicine and Science, this four-part series is designed to empower UW School of Medicine women faculty with tools to thrive in their careers.


  *   Negotiations: Advocating for Self and Others. May 11, 12-1pm
  *   Not Imposter Syndrome. June 14, 9-10am
  *   Difficult Conversations. September 20, 4-5pm
  *   How to Build and Lead Diverse Teams - Strategy. January 12, 2023, 9-10am

For more information and to register, please visit the SOM faculty website<https://bit.ly/3aHoGbp>.


Staff news
[cid:image007.jpg at 01D850E9.569CD370]Staff Spotlight: Sean Greenlee
Our April staff spotlight is on Sean Greenlee, program manager for diversity, equity and inclusion in the Department of Medicine.

Learn more about him on our news site<https://bit.ly/3M2loA8>.

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Core Competency Series
The next DOM Core Competency Series is "A Day in the Life: A Medical Student, Resident, and Fellow Perspective," presented by Katie Hawkins (4th-Year Medical Student), Dr. Linda Liu (Harborview Inpatient Chief Medical Resident) and Dr. Busola Oluwole (Hematology-Oncology Fellow). May 11, 12-1pm, via zoom<https://washington.zoom.us/j/96620350832?pwd=eXlxMGR3cEhhZU1Sc1pNdnhCODltdz09> (Meeting ID: 966 2035 0832, Passcode: 393414)


Diversity, Equity and Inclusion news
Health Equity Conversations
[cid:image009.jpg at 01D850E9.569CD370]The DOM health systems team is supporting Health Equity Conversations, a new limited series podcast hosted by Joshua Liao, associate professor (General Internal Medicine) and associate chair, and featuring people and groups around the country working on payment and other systems change efforts to improve health equity.

The series builds off a prior call to action<https://healthequitypayment.org/> and efforts to raise awareness about these issues in peer-reviewed<https://jamanetwork.com/journals/jama/fullarticle/2780944> and other<https://www.statnews.com/2022/03/29/how-to-fix-the-two-tier-u-s-health-payment-system/> venues. Listen to a brief series introduction by Dr. Liao<https://www.healthsystemscollective.org/hec>.


Education news
Spotlight on resident research
[A person in a suit smiling  Description automatically generated with medium confidence]The Spotlight on Resident Scholarship<https://uwmedres.uw.edu/resident-life/research/spotlight> highlights research, quality improvement, medical education, advocacy, and other scholarly activities of UW Internal Medicine residents.

In their research, "Uncovering relationships between body composition and outcomes from immune checkpoint inhibitor therapy," Dr. Duncan Hussey and collaborators retrospectively used radiographic measures of pre-treatment lean muscle mass and levels of blood albumin in effort to better predict which renal cancer patients will have greater mortality after dual checkpoint inhibitor therapy. This study lays a foundation for future research to examine whether nutritional and body composition biomarkers could be used to personalize counseling and treatment plans for patients with metastatic renal cell carcinoma.

Read more on the Residency website<https://bit.ly/36eoMbQ>.


Research news
Breast cancer treatment linked to increased risk of cardiovascular disease
[cid:image013.jpg at 01D850E9.569CD370]A new study in the Journal of Clinical Oncology shows that women receiving certain common therapies for breast cancer may be at increased risk for heart attack, stroke, heart failure, other cardiovascular events, and death.

Study authors say that even though more women are surviving breast cancer because of the increased effectiveness of treatments, the linkage of cancer therapy to increased cardiovascular events means researchers must now focus on understanding potential mechanisms and toxicities to develop clinical strategies protecting the heart health of breast cancer survivors.

"We hope to raise awareness that women who are breast cancer survivors must receive comprehensive, ongoing follow-up care and monitoring for cardiovascular risk, and scientists and clinicians must prioritize research that will reduce this risk," said Dr. Heather Greenlee, associate professor (Medical Oncology) and lead author of the JCO article.

Read the full story from Hutch News<https://bit.ly/3KEgKrO>.
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Researching the effects of long COVID
[cid:image015.jpg at 01D850E9.569CD370]Doctors generally define long COVID as a post-acute condition that causes a wide range of symptoms for over a month after testing positive for the virus. But some mysteries, like the condition's biggest risk factors, still perplex scientists.

Last month, UW Medicine, Swedish Health Services and the Institute for Systems Biology in Seattle joined the nationwide National Institutes of Health study and will contribute data from Pacific Northwest patients. The study - known as RECOVER<https://bit.ly/38O2oXN> (Researching COVID to Enhance Recovery) - is expected to be the largest and most comprehensive long COVID research effort in the U.S. to date.

"I think it'll give us value essentially in the numbers - the numbers of enrollees and their clinical characterization, and the numbers of blood tests and types of abnormalities we may be able to confirm with larger studies," said Dr. Helen Chu, associate professor (Allergy and Infectious Diseases), and the study's lead UW Medicine investigator.

Read more in "Long COVID grips some Washingtonians and perplexes scientists; new research underway<https://bit.ly/3rjWd49>" in the Seattle Times.


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[cid:image017.jpg at 01D850E9.569CD370]Dr. Brian Kraemer, research professor (Gerontology and Geriatric Medicine) has received $250,000 from the Washington Research Foundation (WRF) to develop small molecules to treat Alzheimer's disease. Kraemer will use the latest funding from WRF to further develop and test the small molecules he has identified, concentrating on their ability to safely inhibit MSUT2 and cross the blood-brain barrier. If successful, it could set the stage for first-in-human studies to develop new AD drugs with his technology. Read the press release from the WRF<https://bit.ly/3KDIbC1>.


Recent publications
Dr. Lindley Barbee, associate professor (Allergy and Infectious Diseases) is lead author of "Management of Neisseria gonorrhoeae in the United States: Summary of Evidence From the Development of the 2020 Gonorrhea Treatment Recommendations and the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infection Treatment Guidelines<https://bit.ly/3rrmayL>" in Clinical Infectious Diseases.

Drs. Michael Boeckh and Grace John-Stewart (Allergy and Infectious Diseases) are co-authors of "Cytomegalovirus Viremia and Clinical Outcomes in Kenyan Children Diagnosed With Human Immunodeficiency Virus (HIV) in Hospital<https://bit.ly/3JGviFZ>" in Clinical Infectious Diseases.

Drs. Melinda Biernacki, Elizabeth Krakow, Paul Martin, Mary Flowers, and Stanley Riddell (Medical Oncology) are co-authors of "Naive T-Cell Depletion to Prevent Chronic Graft-Versus-Host Disease<https://bit.ly/34W3Nd3>" in the Journal of Clinical Oncology.

Dr. Andrew Cowan, associate professor (Medical Oncology) is co-author of "ASTCT Clinical Practice Recommendations for Transplantation and Cellular Therapies in Multiple Myeloma<https://bit.ly/3jA5GQD>" in Transplantation and Cellular Therapy.

Dr. Benjamin Freedman, associate professor (Nephrology) is co-author of "Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice<https://bit.ly/3rrn2Dx>" in Science Translational Medicine.

Dr. Terry Gernsheimer, professor (Hematology) is co-author of "Rilzabrutinib, an Oral BTK Inhibitor, in Immune Thrombocytopenia<https://bit.ly/38GNVwC>" in NEJM.

Dr. Christine Johnston, associate professor (Allergy and Infectious Diseases) wrote "Diagnosis and Management of Genital Herpes: Key Questions and Review of the Evidence for the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines<https://bit.ly/3JGXiZZ>" in Clinical Infectious Diseases.

Dr. Sarah Lee, assistant professor, is lead author, and Dr. Andrew Cowan, associate professor (Medical Oncology) is senior author of "Ciltacabtagene autoleucel. CAR-T therapy targeting B-cell maturation antigen (BCMA), Treatment of multiple myeloma<https://bit.ly/3v5oHzE>" in Drugs of the Future.

Jennifer Logue and Dr. Helen Chu (Allergy and Infectious Diseases) are co-authors of "Detailed analysis of antibody responses to SARS-CoV-2 vaccination and infection in macaques<https://bit.ly/3jFZypY>" in PLOS Pathogens.

Dr. R. Scott McClelland, professor (Allergy and Infectious Diseases) is co-author of "Diagnosis and Management of Trichomonas vaginalis: Summary of Evidence Reviewed for the 2021 Centers for Disease Control and Prevention Sexually Transmitted Infections Treatment Guidelines<https://bit.ly/38H3eFC>" in Clinical Infectious Diseases.

Dr. Andrew Portuguese, fellow, is lead author and Dr. Evan Hall, assistant professor (Medical Oncology) is senior author of "Immune Checkpoint Inhibitor Use in Solid Organ Transplant Recipients: A Systematic Review<https://bit.ly/3riiQG7>" in JNCCN. DOM co-authors are Scott Tykodi, Christopher Blosser, and John Thompson.

Dr.  Eugene Yang, clinical professor (Cardiology) is senior author of "Comparison of American and European Guidelines for Primary Prevention of Cardiovascular Disease: JACC Guideline Comparison<https://bit.ly/37CcuKy>" in the Journal of the American College of Cardiology.


In the news
Dr. Anthony Back, professor (Medical Oncology) talked to KUOW in "Could a psychedelic trip help burned out health care workers cope? This scientist thinks so<https://bit.ly/3KJpj4q>."

Dr. Jocelyn Cooper, R2, is quoted in "Cefazolin may be safe option before surgery for patients with penicillin allergy labels<https://bit.ly/3KAFWj0>" in Healio Asthma/Allergy.

Dr. Christopher Damman, clinical associate professor (Gastroenterology) is quoted in "Adding key foods to a diet will help restore gut health<https://bit.ly/3JFd5Ze>" from UW Medicine Newsroom.

Dr. Mary (Nora) Disis, professor (Medical Oncology) is quoted in "New generation of cancer-preventing vaccines could wipe out tumors before they form<https://bit.ly/3vcsDyH>" in Science.

Dr. Vishesh Kapur, professor (Pulmonary, Critical Care and Sleep Medicine) co-wrote "Look back at the past before 'springing forward'<https://bit.ly/3KE3V0M>" in the Seattle Times.

Dr. John Lynch, professor (Allergy and Infectious Diseases) is quoted in "COVID cases rising in western Washington<https://bit.ly/3JEj6pm>" from KIRO 7 news.

Dr. Arun Sridhar, assistant professor (Cardiology) is quoted in "How the COVID-19 Pandemic Has Taken a Toll on Heart Health<https://cnet.co/3JBNy3j>" in CNET.



Events of interest
Medicine Grand Rounds
Dr. Alvin Calderon, (Virginia Mason Franciscan Health) will present "Growth Mindset in Medical Education" at Medicine Grand Rounds on Friday, April 22, 2022,12-1pm, via zoom<https://washington.zoom.us/j/812197730>.



Weekly Calendar, April 18-22, 2022
Our events calendar is posted on our website<https://medicine.uw.edu/news/trumba-calendar>.


Coming up
2022 PNW Palliative Care Conference
Cambia Palliative Care Center of Excellence is pleased to invite you to the 2022 PNW Palliative Care Conference: "Lifting Voices & Building Bridges: Working Towards an Inclusive Future for Palliative Care." June 13, 8am-4pm. Please register for this event<https://cpcce.uw.edu/news/annual-conference/2022-agenda-register>.

Trauma Stewardship Institute Workshop
UW Medicine and the School of Medicine are partnering with Laura van Dernoot Lipsky and the Trauma Stewardship Institute to address the accumulative toll of the pandemic on UW Medicine healthcare staff and providers through a 2-hour system-wide workshop. Recordings will be posted online for those unable to attend live.
June 21, 4-6pm. Register here<http://discover.uw.edu/MTMxLUFRTy0yMjUAAAGC9mKmnJwnjMoaLOcXVeLaMwTs3bay1GilR5I0B4eODjVFNAEcwrD-sP5C91458N2AIB827n0=>.

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Amy Fields, Editor
(206) 685-3685
amyf at uw.edu<mailto:amyf at uw.edu>


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