[domweek] DOM Week, February 17-21, 2025

[Department of Medicine weekly newsletter via domweek]

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DOM Week
February 14, 2025
News, information, and events of interest from the Department of Medicine <http://bit.ly/1TemKEY>

(If you have items for DOM week, please email amyf at uw.edu<mailto:amyf at uw.edu>)



DEIB news
Save the date: Film screening of Trans Dudes with Lady Cancer
[Portion of a movie poster for "Trans Dudes with Lady Cancer"]All are welcome to join the DOM DEIB Community, DOM LGBTQ+ Council and the Genetic Counseling Graduate Program for a screening of Trans Dudes with Lady Cancer<https://bit.ly/3EBVMM0>, including a Q&A with the filmmakers.

This is short film documenting the journey of two transmasculine people, their families, and their communities, as they navigate breast cancer and ovarian cancer within the medical system.

March 14, 3:30pm, Health Sciences Turner Auditorium (D209). Accessible seating in the front or rear of the auditorium. Please RSVP to save your seat<https://bit.ly/4hwnZ5F>.


Faculty news
Commensality groups
[A group of people sitting around a table, communicating and connecting.]As part of our focus on well-being, we are facilitating commensality groups<https://bit.ly/4gDgmc4> to strengthen community, collegiality, and social connection amongst faculty. Groups consist of 6 to 8 participants meeting monthly to discuss questions relevant to their professional obligations, personal lives, and work-life integration.

Feedback from commensality groups formed in fall 2023 was positive, with participants feeling the groups were helpful in building engagement, connections and community while reducing distress.

Please sign up<https://redcap.link/qb9qapt7> if you are interested in joining a group!

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Faculty spotlight: Anne Larson
[Anne Larson]Distinguished hepatologist Dr. Anne Larson, clinical professor (Gastroenterology) has retired after over 30 years of service. She is nationally recognized for her expertise in hepatology, liver transplantation, and liver cancer and has made significant contributions to medical education, clinical practice, and research.

Learn more about her on our news site<https://bit.ly/4aSH4fM>.


Education news
Continuing accreditation
[cid:image009.jpg at 01DB7EFA.1A8A5A00]The ACGME recently completed its review of our currently accredited training programs. All residency<https://bit.ly/4b8mpVa> and fellowship<https://bit.ly/3EE84DI> programs in the DOM received continuing accreditation status. Additionally, the internal medicine residencies and fellowship programs received no citations or areas for improvement (AFIs). This is a remarkable testament to the exceptional efforts of the programs’ leadership teams and the department’s support. Congratulations to all!


Research news
A roadmap for managing coronary stent underexpansion
[Drs. Primero Ng and Lorenze Azzalini.]A state-of-the-art review published this week in the Journal of the American College of Cardiology<https://bit.ly/4jU5uK0>, presents critical advancements in the diagnosis and treatment of coronary stent underexpansion, a complication of an interventional cardiac procedure used to improve blood flow through blocked arteries.

Lead author of the review is Dr. Primero Ng, acting instructor and fellow in complex coronary therapies, and senior author is Dr. Lorenzo Azzalini, associate professor and director of Interventional Cardiology Research.

Read the full story on our news site<https://bit.ly/4jPbmEd>.

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Novel regimen greatly reduced chronic GVHD in phase 2 study
[Masumi Ueda Oshima]A novel drug regimen tested for the first time by researchers at Fred Hutch Cancer Center has shown great promise in preventing moderate to severe cGVHD after transplant in people who received nonmyeloablative or reduced-intensity conditioning to treat a blood cancer. In a randomized phase 2 study, the Fred Hutch team compared the effects of two drug combinations given to prevent GVHD by suppressing the immune system: sirolimus, cyclosporine and mycophenolate mofetil (SIR/CSP/MMF) and sirolimus, cyclosporine and post-transplant cyclophosphamide (SIR/CSP/PTCy).

The rate of moderate to severe cGVHD one year after transplant was 1% in the latter group, who received PTCy, compared to 28% in the control group. Estimated one-year cGVHD-free relapse-free survival was also better in the PTCy group - 76% vs. 55%.

“PTCy has been a gamechanger for chronic GVHD, and our novel combination of drugs may work even better than previous combinations of drugs with PTCy,” said Dr. Masumi Ueda Oshima, associate professor (Hematology and Oncology) and lead researcher for the study, who was pleased to see that the reduction in cGVHD was not offset by an increased risk of the patient’s cancer returning.

Read the full story from Hutch News<https://bit.ly/41azXMy>.

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Clinical Research Methods course
There’s still time to join! Fellows and junior faculty interested in clinical research are invited to join<https://bit.ly/42FzNhn> a fast-paced comprehensive course in clinical research methods. This 11-week course (Feb 26-May 14) will teach fundamental concepts of epidemiology and biostatistics with direct application of these methods toward the interpretation of contemporary biomedical research. The course will combine out of class reading and video content with in-class problem solving sessions and journal article appraisal. Dr. Bryan Kestenbaum, professor (Nephrology) is the course director. For more information, please visit our website<https://bit.ly/3DAX5H3>.


Recent publications
Dr. Rehana Akter, postdoctoral scholar, is lead author and Dr. Steven Kahn, professor (Metabolism, Endocrinology and Nutrition) is senior author of “Increased Steroidogenic Acute Regulatory Protein (StAR) Contributes to Cholesterol-Induced β-cell Dysfunction<https://bit.ly/4jW3xg0>” in Endocrinology. DOM co-authors are Edward Boyko and Sakeneh Zraika.

Dr. Rachel Bender Ignacio, associate professor, is lead author, and Dr. Adrienne Shapiro, assistant professor (Allergy and Infectious Diseases) is senior author of “Mpox in People with HIV: Prioritizing Interventions for those without HIV Viral Suppression<https://bit.ly/3Qhnr7u>” in Clinical Infectious Diseases. DOM co-authors are Mari Kitahata and Michalina Montaño.

Dr. Jennifer Best, professor (General Internal Medicine) is lead author of “Expanding Community Engagement, Alignment, and Environmental Scanning to Improve a Large Sponsoring Institution’s Strategic Planning Process<https://bit.ly/3QmzosJ>” in the Journal of Graduate Medical Education.

Dr. Gail Jarvik, professor and head (Medical Genetics) is co-author of “Kidney multiome-based genetic scorecard reveals convergent coding and regulatory variants<https://bit.ly/4hRfAJu>” in Science.

Dr. Mehraneh Khalighi, clinical associate professor (General Internal Medicine) is lead author and Dr. Katherine Ritchey, clinical assistant professor (Gerontology and Geriatric Medicine) is senior author of “Agreement Between Provider-Completed and Patient-Completed Preoperative Frailty Screening Using the Clinical Risk Analysis Index: Cross-Sectional Questionnaire Study<https://bit.ly/3WQK8Dq>” in JMIR Perioperative Medicine. DOM co-author is Amy Thomas.

Dr. Allison Mobley (R1) is lead author of “Prescribing methadone in prison predicts linkage to HIV care after release from prison: A randomized and patient preference trial<https://bit.ly/4gDd3BV>” in the International Journal of Drug Policy.

Dr. Hasan Nadeem, R3, is lead author and Dr. Kevin Duan, affiliate instructor (Pulmonary, Critical Care and Sleep Medicine) is senior author of “Association Between Industry Payments and Prescription of Inhaled Medications<https://bit.ly/41evFnc>” in the American Journal of Respiratory Care Medicine. DOM co-authors are Lucas Donovan, Laura Feemster, and David Au.

Dr. Peter Nelson, professor (Hematology and Oncology) is co-author of “Comparative transcriptomics reveals a mixed basal, club, and hillock epithelial cell identity in castration-resistant prostate cancer<https://bit.ly/4b1pp5p>” in PNAS.

Evangelos Nizamis, research scientist, and Dr. Paul Valdmanis, associate professor (Medical Genetics) are co-authors of “CASP8 intronic expansion identified by poly-glycine-arginine pathology increases Alzheimer's disease risk<https://bit.ly/3X0sqgH>” in PNAS.

Dr. Mazyar Shadman, associate professor (Hematology and Oncology) is senior author of “Perspectives on Current Challenges and Emerging Approaches for Lymphoma Management From the First Bridging the Gaps in Leukemia, Lymphoma, and Multiple Myeloma Conference<https://bit.ly/4hxAjSS>” in Clinical Lymphoma, Myeloma & Leukemia and “Outcomes Among Adult Recipients of CAR T-cell Therapy for Burkitt Lymphoma<https://bit.ly/3WVyVS4>” in Blood. DOM co-authors are David Maloney, Brian Till, Alexandre Hirayama, Jordan Gauthier, Ajay Gopal, Stephen Smith, Christina Poh, Ryan Lynch, Chaitra Ujjani, Mengyang Di, and Vikram Raghunathan.

Dr. Ian Stanaway, research scientist (Nephrology) is lead author of “Multi-ancestry meta-analysis of genome-wide association studies discovers 67 new loci associated with chronic back pain<https://go.nature.com/3X02WQm>” in Nature Communications.

Dr. Matthew Triplette, associate professor (Pulmonary, Critical Care and Sleep Medicine) is co-author of “Lung Cancer Screening and Incidental Findings: A Research Agenda. An Official American Thoracic Society Research Statement<https://bit.ly/3X1Zi8V>” in the American Journal of Respiratory and Critical Care Medicine.


In the news
Dr. Bradley Anawalt, professor (General Internal Medicine) is quoted in “Future of transgender athletes uncertain in WA following executive order<https://bit.ly/4hBhdLV>” in the Seattle Times and “What an endocrinologist says about the differences between trans, cisgender athletes<https://n.pr/41h0ms7>” from NPR.

Dr. Rotonya Carr, associate professor and head (Gastroenterology) is quoted in “A Promising Development for Millions of People With Liver Disease<https://nyti.ms/4hVCwYk>” in the New York Times.

Dr. Helen Chu, professor (Allergy and Infectious Diseases) talked to KUOW in “Dr. Helen Chu was ready for Covid. Now she's preparing for the next pandemic<https://bit.ly/410XpKC>.”

Dr. Lawrence Corey, professor (Allergy and Infectious Diseases) is quoted in “NIH slashes overhead payments for research, sparking outrage and lawsuit<https://bit.ly/42PzfW1>” in Science and was featured on ABC nightly news in “Virology expert says NIH funding cuts could be detrimental to life-saving research<https://bit.ly/4hDqByD>.”

Dr. Kiran Dhillon, director of program operations (Hematology and Oncology) is quoted in “The Jellison Family Foundation Is Helping Fund Breakthroughs in Cancer Vaccine Research<https://bit.ly/42UwsLf>” in Sarasota Magazine.

Dr. Scott Hagan, assistant professor (General Internal Medicine) is quoted in “Millions Will See This Super Bowl Ad. Health Experts (and Two Senators) Aren’t Pleased<https://nyti.ms/41fugwP>.” in the New York Times.


Events of interest
Medicine Grand Rounds
Dr. Kevin Winthrop (OHSU) will present the David Park Lecture “Mycobacteria in 2025” at Medicine Grand Rounds on Friday, Feb. 21, 12-1pm, via zoom<https://washington.zoom.us/j/812197730>.

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Quiet week: February 17-21
As we continue to rebuild resilience and focus on mental health, we would like to preserve department-wide quiet weeks throughout the year. During these weeks, we hope that individuals can limit non-essential meetings to recharge and reflect, as well as thoughtfully minimize emails. We realize that this will not be possible for everyone but encourage all to take breaks when they are able.

Upcoming 2025 quiet weeks:

  *   April 7-11
  *   August 4-8
  *   November 24-28
  *   December 22-26


Weekly Calendar, February 17-21, 2025
Our events calendar is posted on our website<https://medicine.uw.edu/news/trumba-calendar>.


Events of interest
Symposium on Climate Change and Clinical Practice
All are invited to attend a free symposium designed to galvanize the UW Medicine system around collective climate action on March 6, 8am-1pm, Center for Urban Horticulture. The symposium will bring together relevant stakeholders for learning, network development, and practical exploration of key topics addressing the implications of climate change for clinical practice and health care systems. Lunch and refreshments will be provided for all speakers and registered attendees. Parking is free. Please register for this event<https://bit.ly/4huksop>.

________________________________

Amy Fields, Editor
amyf at uw.edu<mailto:amyf at uw.edu>


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