[domweek] DOM Week, October 28-November 1, 2024

[Department of Medicine weekly newsletter via domweek]

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DOM Week
October 25, 2024
News, information, and events of interest from the Department of Medicine <http://bit.ly/1TemKEY>

(If you have items for DOM week, please email amyf at uw.edu<mailto:amyf at uw.edu>)


Well-being grants
[cid:image003.jpg at 01DB26F7.11DAEF60]UW Medicine has announced a second year of funding for Well-Being Grants aimed at improving the workplace and learning environment for our community. The grants will support impactful activities, programming, projects and/ or applied research that aligns with the goals of our well-being work. All faculty, staff, and trainees from across UW Medicine (inclusive of administrative, clinical, education and research areas) are encouraged to apply for the grants. Applications are open Oct. 29-Dec. 10. For more information, please visit the UW Medicine OFA website<https://bit.ly/4hePRLA>.


Awards
Call for nominations: 2025 Distinguished Alumni Awards
[cid:image005.jpg at 01DB26F7.11DAEF60]Nominations for the 2025 UW School of Medicine Distinguished Alumni Awards<http://bit.ly/2Se83IV> are now open. Honor the colleagues and classmates who inspire you by nominating them<https://bit.ly/3eVwPvg> for one of four awards: the Distinguished Alumnus/Alumna Award, the Alumni Humanitarian Award, the Alumni Service Award and the Alumni Early Achievement Award. Nominations are due Dec. 31.


Staff news
[Lori Joubert]EDI peer trainer
Lori Joubert, program coordinator (Cardiology) has officially been recognized as an EDI Peer Trainer. She is now certified to deliver Bystander Training on behalf of the UW Medicine Office of Healthcare Equity<https://bit.ly/40iIqwV> (OHCE). Certified EDI peer trainers are indispensable members of OHCE's training team.


Faculty news
[Sarah Holton]Dr. Sarah Holton, acting instructor (Pulmonary, Critical Care and Sleep Medicine) won the 3rd place basic science prize at the National Jewish Health Respiratory Disease Young Investigators' Forum. She presented: "Identification of pro-fibrotic mononuclear phagocyte subpopulations in cryobiopsies from patients with early Interstitial Lung Disease using spatial transcriptomics." The Young Investigators' Forum provides career development and research opportunities for fellows and early career faculty and has been a catalyst for groundbreaking discoveries.


Clinical news
The Bruce Protocol: A 75-year legacy of innovation
[Dr. Robert Bruce and patient]When UW Medicine cardiologist Robert A. Bruce, MD, developed his technique for evaluating cardiac function and physical fitness, it revolutionized the way clinicians assessed patients for cardiovascular disease. His method, the Bruce Protocol, opened the door for valuable advancements in cardiovascular diagnostics. And 75 years after capturing the first treadmill results, it remains the foundation for exercise stress testing.

"The brilliance of his protocol was putting together the concept of provoking physiologic stress without harming the patient in order to know when to intervene," said Dr. James Kirkpatrick, professor (Cardiology) and director of the Echocardiology Laboratory at UW Medicine's Heart Institute. "The subsequent work built on this method has allowed us to risk-stratify patients and develop new diagnostic technologies."

The protocol did more than improve patient care. It also launched the Division of Cardiology down a decades-long path of innovation.

Read more on our news site<https://bit.ly/4hggYpM>.


Research news
Global health 2050: the path to halving premature death by mid-century
[David Watkins]A report published this month in The Lancet<https://bit.ly/4dWdo13> focuses on a global concern: premature death. It argues, optimistically, that countries can cut their populations' risk of premature death in half by 2050, if they choose.

"Our main message is that countries can reduce their populations' risk of premature death by 50% by 2050, compared to 2019. We call this goal '50 by 50,' said Dr. David Watkins, associate professor (General Internal Medicine) and co-author of the study. "Our research concluded that this goal is feasible for countries both rich and poor."

The researchers found that just 15 health conditions account for most of the avoidable death under 70. Focusing health spending on these conditions could help countries achieve the 50 by 50 goal. Watkins led the part of the report that discusses how health systems and financing must change to meet this goal.

Learn more through a Q&A with Dr. Watkins and UW Medicine Newsroom<https://bit.ly/40gvQyh>.

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Infectious disease experts propose trials network dedicated to immunocompromised patients
[Joshua Hill]The COVID-19 pandemic made plain what many patients, clinicians and researchers have known for decades: people with weakened immune systems are much more vulnerable to infectious diseases. But immunocompromised patients are usually left out of large clinical trials that assess new treatments and vaccines, leaving a data gap that hampers clinical care.

Last month, experts across disciplines, from infectious disease clinicians to regulators to representatives from the pharmaceutical industry, convened at the inaugural ImmunOptimize workshop in Bethesda, MD, to brainstorm strategies to address the unmet needs of immunocompromised patients.

"We need roots, not parachutes," said Fred Hutch Cancer Center infectious disease expert Dr. Joshua Hill, associate professor (Allergy and Infectious Diseases) who headed the ImmunOptimize scientific committee. "We need a grassroots effort to address the unmet needs of immunocompromised patients. The time is right to bring the conversations to the forefront."

Learn more from Hutch News<https://bit.ly/3YvvQcw>.


Recent publications
Dr. Tara Babu, assistant professor (Allergy and Infectious Diseases) is lead author of "Next-Generation SARS-CoV-2 Vaccine Formulations and Alternative Routes of Administration<https://bit.ly/4eVzLFi>" in the Journal of Infectious Diseases.

Joshua Bis, research scientist, and Dr. Bruce Psaty, professor (General Internal Medicine) are co-authors of "Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries<https://go.nature.com/48h1PQV>" in Nature Genetics.

Dr. Petter Bjornstad, professor (Metabolism, Endocrinology and Nutrition) is senior author of "Attenuated kidney oxidative metabolism in young adults with type 1 diabetes<https://bit.ly/4egkMVr>" in JCI. DOM co-author is Ian de Boer. Dr. Bjornstad is also senior author of "Proteomic Analysis Uncovers Multi-Protein Signatures Associated with Early Diabetic Kidney Disease in Youth with Type 2 Diabetes Mellitus<https://bit.ly/3Uh1nMz>" in the Clinical Journal of the American Society of Nephrology. DOM co-authors are Phoom Narongkiatikhum and Ian de Boer.

Dr. Helen Chu, professor (Allergy and Infectious Diseases) wrote "A Perspective on Vaccinology<https://bit.ly/3Um0cvy>" in the Journal of Infectious Diseases and is senior author of "Maternal immunization<https://bit.ly/40ebt4V>" in the Journal of Infectious Diseases. DOM co-author is Collrane Frivold.

Dr. Ian de Boer, professor (Nephrology) is co-author of "Albuminuria and Rapid Kidney Function Decline as Selection Criteria for Kidney Clinical Trials in Type 1 Diabetes Mellitus<https://bit.ly/40iOQw7>" in the Clinical Journal of the American Society of Nephrology.

Dr. Nicholas Johnson, associate professor (Pulmonary, Critical Care and Sleep Medicine) is co-author of "Effectiveness of the original monovalent mRNA COVID-19 vaccination series against hospitalization for COVID-19-associated venous thromboembolism<https://bit.ly/48j1wVO>" in the Journal of Infectious Diseases.

Dr. Masumi Ueda Oshima, associate professor, is lead author and Dr. Rainer Storb, professor (Hematology and Oncology) is senior author of "Characterization of clonal dynamics using duplex sequencing in donor-recipient pairs decades after hematopoietic cell transplantation<https://bit.ly/3A1ReNb>" in Science Translational Medicine. DOM co-authors are Jesse Salk, Stephanie Lee, Mary Flowers, and Jerald Radich.

Dr. Mayuree Rao, acting instructor (General Internal Medicine) is co-author of "Demographic, Social, Behavioral, and Clinical Characteristics Associated with Long-Term Opioid Therapy and Any Opioid Prescription in High-Risk VA Patients<https://bit.ly/3UltxWW>" in the Journal of General Internal Medicine.

Drs. Thomas Rea, professor (General Internal Medicine) and Peter Kudenchuk, professor (Cardiology) are co-authors of "A Comparison of Ketamine to Midazolam for the Management of Acute Behavioral Disturbance in the Out-of-Hospital Setting<https://bit.ly/4e84NZu>" in the Annals of Emergency Medicine.

Dr. Pradeep Singh, professor (Pulmonary, Critical Care and Sleep Medicine) is senior author of "Elexacaftor/tezacaftor/ivacaftor's effects on cystic fibrosis infections are maintained, but not increased, after 3.5 years of treatment<https://bit.ly/4eRX7vz>" in JCI.

Dr. Susan Wong, associate professor (Nephrology) is lead author of "Providers' Experiences Discussing Care for Patients with Kidney Failure Who Forgo KRT: A National Qualitative Study<https://bit.ly/40k6Dmy>" in the Clinical Journal of the American Society of Nephrology. DOM co-authors are Julie Chotivatanapong and Daniel Lam.


In the news
Dr. Christopher Damman, clinical associate professor (Gastroenterology) is quoted in "Keeping your gut healthy and happy: 'It's a daily practice'<https://bit.ly/4fcZb0N>" in the Seattle Times.

Dr. Ajay Gopal, professor (Hematology and Oncology) is quoted in "Is nivolumab superior to standard of care for classic Hodgkin lymphoma?: Phase III trial finds improved PFS, side effects with nivolumab+chemo<https://bit.ly/4hgMAvc>" in The Cancer Letter.

Dr. Joshua Hill, associate professor (Allergy and Infectious Diseases) is quoted in "What Does It Mean to Be Immunocompromised?<https://nyti.ms/4f7gQXy>" in the New York Times.

Dr. Eric Larson, affiliate professor (General Internal Medicine) is quoted in "Trump's and Harris' vitriolic attacks on each other's mental health are shameful<https://bit.ly/3BY5sPP>" in STAT.

Dr. Suzanne Watnick, professor (Nephrology) is quoted in "How Hurricane Helene is threatening dialysis patients<https://bit.ly/4ffduBW>" in The Hill.

Dr. Eugene Yang, clinical professor (Cardiology) is quoted in "How to Fix Health Data for People with Asian and Pacific Islander Heritage<https://bit.ly/3NAWSJa>" in Scientific American.



Weekly Calendar, October 28-November 1, 2024
Our events calendar is posted on our website<https://medicine.uw.edu/news/trumba-calendar>.


Coming up
Current concepts in medication therapy
In this course, speakers will highlight innovations in drug therapies, review new indications for old medications, and discuss medication side effects and drug interactions. The course designed for family physicians and other primary care providers including internists, pediatricians, osteopathic physicians, physician assistants, nurse practitioners, pharmacists and others interested in medication management. Dec. 9-10 (webinar). For more information and to register, please visit the UW CME website<https://bit.ly/3NDTJbv>.



________________________________

Amy Fields, Editor
amyf at uw.edu<mailto:amyf at uw.edu>


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