[domweek] DOM Week, November 21-25, 2022

[Department of Medicine weekly newsletter]

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DOM Week
November 18, 2022
News, information, and events of interest from the Department of Medicine <http://bit.ly/1TemKEY>

(If you have items for DOM week, please email amyf at uw.edu<mailto:amyf at uw.edu>)



Awards
[cid:image027.jpg at 01D8FB6C.F3F32E70]Outstanding Research Mentor Awards
Nominated by students throughout WWAMI, 8 mentors were selected by the School of Medicine Scholarship Committee to receive Outstanding Research Mentor Awards, including the following from the Department of Medicine: Dr. Cory Simpson, assistant professor (Dermatology) and Dr. Namrata Singh, assistant professor (Rheumatology).

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[cid:image028.jpg at 01D8FB6C.F3F32E70]King County Medical Society Foundation Awards
Congratulations to the following who received King County Medical Society Foundation Awards: Dr. Anita Chopra, clinical instructor (General Internal Medicine) received the Reducing Health Disparities Award; Dr. Jeffrey Duchin, professor (Allergy and Infectious Diseases) received the Public Health Achievement Award; and Dr. Sabine von Preyss-Friedman, clinical associate professor emeritus (Gerontology and Geriatric Medicine) received the Covid-19 Leadership Award.


Faculty news
Examining genetics and genomics workforce diversity
[cid:image029.jpg at 01D8FB6C.F3F32E70]Dr. Fuki Hisama, professor (Medical Genetics) was on the American College of Medical Genetics and Genomics (ACMG) Workforce Diversity Initiative Advisory Group that assessed diversity in the medical genetics workforce. The ACMG joined major genetics and genomics organizations in releasing the Human Genetics & Genomics Workforce Survey Report<https://bit.ly/3UIwHlA>. “A diverse genetics workforce is key to realizing the benefits of medical genetics for everyone,” she said. “This survey is a major milestone toward advancing the ACMG mission and the key findings will help identify opportunities to improve recruitment, training and retention efforts.”

Dr. Hisama has also been named the inaugural section editor for clinical genetics for Genetics in Medicine Open, a new open access journal of the American College of Medical Genetics and Genomics, launching in January 2023.
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Dr. Paul Nghiem, professor and head (Dermatology) delivered the fifteenth annual Rodan-Fields Lecturer in Dermatology at Stanford last week. He presented “Merkel cell carcinoma: An often-lethal, virus-driven cancer provides insights into adaptive and innate anti-tumor immunity.”


Education news
Call for mentors and coaches for residents from underrepresented backgrounds
The Internal Medicine Resident Diversity Committee (RDC) is looking for mentors/career coaches. They would like to create an active list of faculty members and their associated clinical and research interests that can be used by RDC members to find someone with whom they may be able to connect.

The goal would be to better link residents with faculty members that share their diverse backgrounds and/or diverse clinical and research interests. Faculty members linked with residents would be able to provide professional advice and guidance, or potentially consider collaboration on research projects.

The RDC would like to create this list with a goal, in part, of getting faculty recognition for the time and effort that they contribute to this activity. If you are interested, please complete this form<https://forms.office.com/Pages/ResponsePage.aspx?id=W9229i_wGkSZoBYqxQYL0miEu_4eMj5PkR1LpIVcXZFURVo2SzY0QTJYWkZQUzkyNkExNlhaTEhXSy4u>.
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Call for applications: Palliative care research fellowship
Applications are now being accepted for the Cambia Palliative Care Center of Excellence palliative care research fellowship. This post-doctoral research fellowship is funded by a T32 Training Grant Award from the National Heart, Lung, and Blood Institute and designed for post-doctoral fellows interested in a 1-2 year fellowship to learn to conduct palliative care research. Applications are due Dec. 15 for positions to start in 2023. Please feel free to share with people you think may be interested in this opportunity. More information about the fellowship program can be found on their website<https://cpcce.uw.edu/our-work/cpcce-research-fellowship>.


Clinical news
Meeting the needs of people facing winter homelessness
[cid:image031.jpg at 01D8FB6C.F3F32E70]Cold weather brings dire consequences to the unhoused. Drs. Leslie Enzian and Darrell Owens care for those experiencing homelessness. For 27 years, Enzian has worked as a primary care provider for people experiencing homelessness at UW Medicine Pioneer Square Clinic. She has also been the medical director at the Edward Thomas House Medical Respite since 1996. Owens has practiced hospice and palliative care for 30 years. His work focuses on the symptoms that impact the quality of life, including physical or emotional pain, and guiding patients through difficult decision making processes. Read the full story from the Seattle Medium<https://bit.ly/3GpnlXX>.


Research news
Award will fund research into new metastatic prostate cancer therapies
[cid:image032.png at 01D8FB6C.F3F32E70]For about 70 years, prostate cancer researchers have known that the male sex hormone testosterone, an androgen, along with androgen receptor signaling on prostate cancer cells, are linked to survival rates in prostate cancer.

“We’ve been really effective at blocking that hormone, that target, in prostate cancer,” said Dr. John Lee, assistant professor (Medical Oncology). “But it’s not a cure, not in metastatic disease. It will make the disease regress and be controlled for a couple of years, but eventually the prostate cancer will figure out a way to keep going, independent of androgens and sometimes independent of androgen receptors.”

A three-year, $750,000 grant from the San Antonio, Texas-based Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation will allow Lee and Fred Hutch collaborators Drs. Pete Nelson and Roland Strong to explore new treatment options, specifically through the use of immunotherapy.

Learn more from Hutch News<https://bit.ly/3ECnyWf>.

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Highly cited researchers
Congratulations to those who have been selected as Highly Cited Researchers from the Web of Science Group. Their work has been identified as being among the most valuable and significant in the field. Very few researchers earn this distinction – writing the greatest number of reports, officially designated by Essential Science Indicators (ESI) as Highly Cited Papers. In addition, these reports rank among the top 1% most cited works for their subject field and year of publication in the Web of Science, earning them the mark of exceptional impact.

2022 DOM Highly Cited Researchers
William Banks, Gerontology and Geriatric Medicine
Michael Boeckh, Allergy and Infectious Diseases
Gary Lyman, Medical Oncology
David Maloney, Medical Oncology
Peter Nelson, Medical Oncology
Ganesh Raghu, Pulmonary, Critical Care and Sleep Medicine
Stanley Riddell, Medical Oncology
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Kidney Disease: Improving Global Outcomes
[cid:image033.jpg at 01D8FB6C.F3F32E70]Dr. Ian de Boer, professor (Nephrology) co-chaired the Kidney Disease: Improving Global Outcomes (KDIGO) 2022 Clinical Practice Guideline for Diabetes Management in Chronic Kidney Diseases (CKD). The guideline<https://kdigo.org/wp-content/uploads/2022/10/KDIGO-2022-Clinical-Practice-Guideline-for-Diabetes-Management-in-CKD.pdf> is designed to apply to a broad population of patients with diabetes and CKD, while being mindful of implications for policy and payment. Type 1 and type 2 diabetes are both addressed, with differences in approach to management highlighted when appropriate.

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New in vivo approach to treat sickle cell disease
[cid:image034.jpg at 01D8FB6C.F3F32E70]Drs. Chang Li, research assistant professor, and André Lieber, professor (Medical Genetics) recently met with former NIH Director Dr. Francis Collins, when he visited the University of Washington to discuss their new in vivo approach to treat Sickle Cell Disease (SCD) and beyond.

They said they were impressed by how many details Collins already knew about their studies in the SCD mouse model. Li and Lieber provided Collins with a realistic idea about their approach, the potential, and the hurdles that need to be addressed.

Learn more on our news site<https://bit.ly/3EfZxTl>.
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Cystic Fibrosis Foundation Grants
Several faculty members in the Division of Pulmonary, Critical Care and Sleep Medicine have received funding from the Cystic Fibrosis Foundation. Drs. Kathleen Ramos and Christopher Goss, in collaboration with Drs. Siddhartha Kapnadak, Eric Morrell and Erika Lease received a Leadership and Design Grant to support gathering preliminary data about the use of prophylactic azithromycin after lung transplant and determine the feasibility of a definitive multicenter clinical trial within the Cystic Fibrosis Lung Transplant Consortium.

Drs. Christopher Goss and Pradeep Singh received $5.2 million for a new project titled, “Standardizing Treatments for Pulmonary Exacerbations: A platform for evaluating treatment decisions to improve outcomes (STOP360)”. Dr. Pavan Bhatraju, co-investigator, will lead a sub-study evaluating antibiotic associated nephrotoxicity in participants in STOP360.


Recent publications
Dr. Helen Chu, associate professor (Allergy and Infectious Diseases) is co-author of “Imprinted antibody responses against SARS-CoV-2 Omicron sublineages<https://bit.ly/3DCWWUv>” in Science.

Dr. Ann Collier, professor emeritus (Allergy and Infectious Diseases) is co-author of “Proteomic Signature of Subclinical Coronary Artery Disease in People With HIV: Analysis of the REPRIEVE Mechanistic Substudy<https://bit.ly/3tBSZtt>” in the Journal of Infectious Diseases.

Drs. Laura Crisa, associate professor, is lead author, and Dr. Vincenzo Cirulli, associate professor (Metabolism, Endocrinology and Nutrition) is senior author of “Bone marrow chimerism breaks the barrier to pancreatic islet transplantation<https://bit.ly/3hNlQIO>” in Cell Reports.

Dr. Mehraneh Khalighi, clinical associate professor, is lead author, and Dr. Paul Cornia, associate professor (General Internal Medicine) is senior author of “Preoperative Insulin Intensification to Improve Day of Surgery Blood Glucose Control<https://bit.ly/3tFtHKY>” in Federal Practitioner.

Dr. Sylvia Lee, associate professor (Medical Oncology) is co-author of “Non-viral precision T cell receptor replacement for personalized cell therapy<https://go.nature.com/3hGYPXY>” in Nature.

Dr. A. McGarry Houghton, professor (Pulmonary, Critical Care and Sleep Medicine) is senior author of “Annexin A2/TLR2/MYD88 pathway induces arginase 1 expression in tumor-associated neutrophils<https://bit.ly/3AjnOHd>” in JCI.

Dr. Ganesh Raghu, professor (Pulmonary, Critical Care and Sleep Medicine) is senior author of “Quantitative computed tomography of the chest for fibrotic lung diseases: Prime time for its use in routine clinical practice?<https://bit.ly/3EAWdnx>” in Respirology and lead author of “Randomized Phase IIa Clinical Study of an Anti-αvβ6 Monoclonal Antibody in Idiopathic Pulmonary Fibrosis<https://bit.ly/3hEThNv>” and “A Phase IIb Randomized Clinical Study of an Anti-αvβ6 Monoclonal Antibody in Idiopathic Pulmonary Fibrosis<https://bit.ly/3O5W52p>” in the American Journal of Respiratory and Critical Care Medicine.

Dr. Mazyar Shadman, associate professor (Medical Oncology) is lead author of “Zanubrutinib in patients with previously treated B-cell malignancies intolerant of previous Bruton tyrosine kinase inhibitors in the USA: a phase 2, open-label, single-arm study<https://bit.ly/3UQ1aP0>” in Lancet Haematology.

Dr. Rashmi Sharma, associate professor (General Internal Medicine) is co-author of “Racism in Palliative Care Research: We Still have a Ways to Go<https://bit.ly/3X9vANr>” in the Journal of Pain and Symptom Management.


In the news
Drs. John Amory, professor (General Internal Medicine) and Stephanie Page, professor and head (Metabolism, Endocrinology and Nutrition) are quoted in “After decades of setbacks, scientists make strides toward the holy grail of male birth control<https://bit.ly/3X15WKO>” in STAT.

Dr. Martha Billings, associate professor (Pulmonary, Critical Care and Sleep Medicine) is quoted in “Why You Wake Up in the Night (And How to Stop)<https://bit.ly/3UGNA02>” from Right as Rain.

Dr. Rotonya Carr, associate professor and head (Gastroenterology) is quoted in “In armadillos, leprosy expands healthy liver tissue. Could that tell us something about regenerating our own?<https://bit.ly/3hYo4Vu>” in STAT.

Dr. Mary (Nora) Disis, professor (Medical Oncology) is quoted in “Breast cancer vaccine shows promise in early trial<https://bit.ly/3V0Etae>” in The Hill: Changing America.

Dr. Irl Hirsch, professor (Metabolism, Endocrinology and Nutrition) is quoted in “Insulin used to be affordable — and then, seemingly out of nowhere, it wasn't. Why?<https://bit.ly/3ED7KCu>” in Salon.

Dr. Douglas Paauw, professor (General Internal Medicine) wrote “How Can I Keep From Losing My Mind?<https://wb.md/3tt4yDf>” for Medscape.

Dr. Coralynn Sack, assistant professor (General Internal Medicine) is quoted in “What the Air Quality Index doesn't tell us about smoke dangers<https://bit.ly/3Af2Zga>” in Crosscut.

Dr. Ellen Schur, professor (General Internal Medicine) wrote the blog post “Ask a Doctor: Why am I always hungry?<https://wapo.st/3GhCDOm>” in the Washington Post.


Weekly Calendar, November 21-25, 2022
Our events calendar is posted on our website<https://medicine.uw.edu/news/trumba-calendar>.


Coming up
Faculty promotion Q&A session
Dr. Cynthia Ko, professor (Gastroenterology) and associate chair for faculty affairs, will be holding an informational session on faculty promotion processes and criteria on Wednesday, Nov. 30, from 12-1pm, via zoom<https://washington.zoom.us/j/96495124528?pwd=SDEyNHZ6Y2pyc1FQVlZCcW1pVHhVZz09> (Meeting ID: 964 9512 4528, Passcode: 340340)

Current concepts in medication therapy
This CME conference will highlight innovation in drug therapies, review new indications for old medications, and discuss medication side effects and drug interactions. Speakers include DOM faculty from Allergy and Infectious Diseases, Cardiology, Gastroenterology, General Internal Medicine, Metabolism, Endocrinology and Nutrition, and Pulmonary, Critical Care and Sleep Medicine. Dec. 12-13. For more information and to register, please visit the CME website<https://bit.ly/3ER130l>.


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Amy Fields, Editor
amyf at uw.edu<mailto:amyf at uw.edu>


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