[domweek] DOM Week, November 7-11, 2022

[Department of Medicine weekly newsletter]

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DOM Week
November 4, 2022
News, information, and events of interest from the Department of Medicine <http://bit.ly/1TemKEY>

(If you have items for DOM week, please email amyf at uw.edu<mailto:amyf at uw.edu>)



Awards
[cid:image033.jpg at 01D8F06D.F360D2A0]Dr. William Banks, professor (Gerontology and Geriatric Medicine) was honored with the Viktor Mutt lectureship award at the International Society for Bioactive Peptides meeting. The Viktor Mutt lectureship was established in recognition of the fundamental research of Viktor Mutt (1923-1998) in the field of gastrointestinal peptide hormones and neuropeptides. Dr. Banks was awarded for his outstanding work on the transportation of neuropeptides through the brain blood barrier and the study of their functional implication.

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[cid:image034.jpg at 01D8F06D.F360D2A0]Physician Assistant of the Year
Congratulations to Gabrielle Zecha, PA-C, MHA, associate medical director at Fred Hutchinson Cancer Center (FHCC) and teaching associate (Medical Oncology), who was awarded "Physician Assistant of the Year" by the Washington Academy of Physician Assistants last week at their annual conference. She was awarded this for her mentorship, leadership of the FHCC advanced practice providers through the turmoil of the last several years, and overall excellence as a physician assistant.


Faculty news
In memoriam: Deborah Kippen
[cid:image035.jpg at 01D8F06D.F360D2A0]Dr. Deborah Kippen passed away this summer at the age of 71. She helped build and was medical director of the Pioneer Square Clinic from 1982-1998. A trailblazer in expanding the rights of women health care providers in the University of Washington medical system, she worked to provide equal opportunities for working mothers and to increase the capacity for nurse practitioners to improve patient access.

She also founded the first homeless medical respite program in Seattle, to provide a safe and clean place for homeless patients who were not sick enough to require overnight care in a hospital to recover from short-term health problems, such as minor trauma, chemotherapy treatments for cancer, and newly diagnosed chronic diseases.

A memorial fund<https://bit.ly/3U0hkF3> has been set up in honor of her vision, hard work, commitment to health equity, and her service as medical director of the Pioneer Square Clinic. All proceeds will go to the Pioneer Square Clinic and the care they provide their patients. For information on a memorial gathering, please contact Dr. Nancy Sugg at sugg at uw.edu<mailto:sugg at uw.edu>.

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Save the date: Faculty promotion Q&A session
Dr. Cynthia Ko, professor (Gastroenterology) and associate chair for faculty affairs, will be holding an informational session on faculty promotion processes and criteria on Wednesday, Nov. 30, from 12-1pm, via zoom<https://washington.zoom.us/j/96495124528?pwd=SDEyNHZ6Y2pyc1FQVlZCcW1pVHhVZz09> (Meeting ID: 964 9512 4528, Passcode: 340340)


Education news
[Provider headshot ofJason F. Deen, MD]Prioritizing Native Health
"It's been well documented that if a patient is cared for by a doctor who looks like them, is from their culture, and understands them and their family that they are more likely to trust that person and follow their recommendations," says Jason Deen, MD, FAAP (Blackfeet), associate professor of pediatrics and medicine (Cardiology) and vice chair for equity, diversity and inclusion in the Department of Pediatrics.

Unfortunately, for many American Indians and Alaska Natives, it's difficult to find a doctor who understands their culture or background, in part, because there are so few Native physicians. Moreover, many people within these communities experience profound health inequities and face multiple systemic barriers to accessing the care they need.

The Indian Health Pathway trains physicians to provide culturally humble care for Indigenous people. The first Native American to graduate from the UW School of Medicine, Dr. Walt Hollow, a member of the Assiniboine and Sioux Tribes, started the Indian Health Pathway in 1992, making it the longest running pathway at the School.

"As an institution, we can augment the number of Indigenous physicians who are caring for these communities and augment the training of non-Native allies who are destined to work in Indian country," says Deen, who is also the current director of the Indian Health Pathway.

Learn more from UW Medicine<https://bit.ly/3gLJPr5>.

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Reconnection event
Supporting the well-being of our community is one of our highest priorities, and why we started the pilot reconnect event seed funding program<https://bit.ly/3DsmiDh>. The first group to reconnect was the IM residents in the Clinician Educator Pathway, who went curling! If you are interested in reconnecting, funds are still available<https://bit.ly/3DsmiDh> to plan an event.

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Clinical Research Methods course
Fellows and junior faculty interested in clinical research are invited to join a fast-paced comprehensive online course in clinical research methods. Co-sponsored by the Department of Medicine and the Department of Pediatrics, this 11-week course will teach fundamental concepts in epidemiology and biostatistics and apply these methods toward the interpretation of articles from the published literature. Dr. Bryan Kestenbaum, professor (Nephrology) is the course director. For more information, please visit our website<https://bit.ly/3DAX5H3>.


Research news
Breast cancer vaccine safely generates anti-tumor immunity
[cid:image038.jpg at 01D8F06D.F360D2A0]An experimental vaccine against breast cancer safely generated a strong immune response to a key tumor protein, according to a recent report published in JAMA Oncology<https://bit.ly/3FKkGYw>. The findings suggest the vaccine may be able to treat different types of breast cancer.

"Because this was not a randomized clinical trial, the results should be considered preliminary, but the findings are promising enough that the vaccine will now be evaluated in a larger, randomized clinical trial," said lead author Dr. Mary (Nora) Disis, professor (Medical Oncology), and director of the Cancer Vaccine Institute

The phase I trial was designed to evaluate the safety of a vaccine that targets a protein called human epidermal growth factor receptor 2 (HER2) and to see if it generated an immune response to the protein.

Read the full story from UW Medicine Newsroom<https://bit.ly/3U8UQSb>.
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Complexity of diagnosing and managing long COVID
[cid:image039.jpg at 01D8F06D.F360D2A0]A study of veterans showed great uncertainty about whether to attribute symptoms to long COVID or to patients' other existing conditions. The study, published this week in JAMA Network Open<https://bit.ly/3E36oRw>, examined a national random sample of veterans with prior COVID infection and a diagnostic code for long COVID. The researchers' qualitative analysis of electronic health records showed frequent substantial clinical uncertainty about whether patients' symptoms stemmed from long COVID or from their other health conditions, explained Dr. Ann O'Hare, professor (Nephrology) and principal investigator with the VA COVID-19 Observational Research Collaboratory.

"This (uncertainty) typically led to additional diagnostic testing and specialist referral, which could lead to fragmented and potentially burdensome care," O'Hare said.

Read more on our news site<https://bit.ly/3T6LuoT>.
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Machine learning analysis of right heart failure after left ventricular assist device implantation
[cid:image040.jpg at 01D8F06D.F360D2A0]For decades, left ventricular-assist devices (LVADs) have extended the lives of people whose hearts have grown too weak to effectively pump blood to the body. For upward of 20% of those patients, though, an LVAD implant gives rise to a dreaded complication: Their right ventricle fails, typically within days.

Knowing beforehand which patients are at a higher risk to develop right-heart failure might enable doctors to reduce that likelihood. Researchers reported findings<https://bit.ly/3sMF0Rc> this week of a machine-learning analysis of 186 pre-implant patient factors, revealing the 30 most strongly associated with right-heart failure among a population of 19,595 first-time LVAD recipients.

"We had two objectives with this study: to help predict which patients will develop this complication and to find out if there are factors we can optimize to lower the risk of right-heart failure before we implant the LVAD," said Dr. Song Li, a heart failure cardiologist at the UW Medicine Heart Institute and the paper's senior author. Lead author is Dr. Arjun Bahl, R3.

Read the full story from UW Medicine Newsroom<https://bit.ly/3U7BkoG>.
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Spatiotemporal high-resolution prediction of wildfire smoke exposure: Leveraging satellite remote sensing and low-cost sensor data
[cid:image041.jpg at 01D8F06D.F360D2A0]Wildfire activity has significantly increased over the past decades, including in the western U.S. However, a major impediment to comprehensive epidemiological and environmental justice analyses regarding wildfire smoke is the lack of accurate exposure estimates.

Dr. Joel Kaufman, professor (General Internal Medicine) is part of the team that has received funding from the UW Population Health Initiative 2022 pilot research grant program<https://bit.ly/3DS4N0M>. Their pilot study aims to build a "proof-of-concept" framework for spatiotemporally high-resolution wildfire PM2.5 exposure estimates (1 km, daily-level) in Washington. These future large-scale wildfire smoke data will serve as the foundation of extensive community-based applications and population-based health research.

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[Christopher W. Peterson]
Dr. Christopher Peterson, research associate professor (Medical Oncology) has received an R01 for his project, "Developing Durable, Env-Boosted CAR T Cells for HIV Cure."


Recent publications
Dr. Maralyssa Bann, assistant professor (General Internal Medicine) is lead author of "Implementing a Social Determinants of Health Curriculum in Undergraduate Medical Education: A Qualitative Analysis of Faculty Experience<https://bit.ly/3Nyx93p>" in Academic Medicine.

Dr. Lauren Beste, associate professor (General Internal Medicine) is senior author of "Hepatitis B Virus-related Care Quality in Patients With Hepatitis B/Human Immunodeficiency Virus Coinfection Versus Hepatitis B Monoinfection: A National Cohort Study<https://bit.ly/3sWxJ1a>" in Clinical Infectious Diseases.

Dr. Shailender Bhatia, professor (Medical Oncology) is co-author of "Combination of the STING Agonist MIW815 and PD-1 Inhibitor Spartalizumab in Advanced/Metastatic Solid Tumors or Lymphomas: An Open-label, Multicenter, Phase Ib Study<https://bit.ly/3E2hPbV>" in Clinical Cancer Research.

Dr. Benjamin Freedman, associate professor (Nephrology) is co-author of "Adult human kidney organoids originate from CD24+ cells and represent an advanced model for adult polycystic kidney disease<https://go.nature.com/3DKjClG>" in Nature Genetics.

Dr. Matthew Golden, professor, is lead author and Dr. Judith Wasserheit, professor (Allergy and Infectious Diseases) is senior author of "Monkeypox - A Sobering Sentinel for Pandemic Preparedness and Sexual Health System Capacity<https://bit.ly/3Wu0j7S>" in the New England Journal of Medicine.

Dr. Geoffrey Gottlieb, professor (Allergy and Infectious Diseases) is co-author of "Effect of Human Immunodeficiency Virus Infection on Human Papillomavirus Clearance among Women in Senegal, West Africa<https://bit.ly/3t0SAAk>" in the Journal of Infectious Diseases.

Dr. George Ioannou, professor (Gastroenterology) is co-author of "Mitochondrial dysfunction reactivates α-fetoprotein expression that drives copper-dependent immunosuppression in mitochondrial disease models<https://bit.ly/3h8aj6u>" in JCI.

Dr. Andrew Portuguese, fellow (Hematology) is lead author, and Dr. Hans Joachim Deeg, professor (Medical Oncology) is senior author of "Transplantation for myeloid neoplasms with antecedent solid tumor<https://bit.ly/3UjEGVY>" in Cancer. DOM co-author is Aya Albittar.

Dr. Alison Roxby, associate professor (Allergy and Infectious Diseases) is senior author of "Starting to have sexual intercourse is associated with increases in cervicovaginal immune mediators in young women: a prospective study and meta-analysis<https://bit.ly/3UboK7P>" in eLife. DOM co-authors are Anna Wald and Florian Hladik.

Dr. Judith Tsui, professor (General Internal Medicine) is senior author of "Qualitative inquiry into perceptions of HIV pre-exposure prophylaxis among people who inject drugs living with hepatitis C in Seattle, WA, USA<https://bit.ly/3sX4tHL>" in Harm Reduction Journal. DOM co-authors are Elenore Bhatraju, Sara Glick, Joanne Stekler and Alexander Gojic.


In the news
Dr. Anthony Back, professor (Medical Oncology) is quoted in "Single Dose of Synthetic 'Magic Mushroom' Psilocybin Eases Severe Depression<https://bit.ly/3U5fZww>" in Healthline.

Dr. Helen Chu, associate professor (Allergy and Infectious Diseases) is quoted in "Treatment approved in Europe to prevent RSV in infants could be coming to the US soon<https://cnn.it/3FKdBa6>" in CNN Health.

Dr. Seth Cohen, clinical associate professor (Allergy and Infectious Diseases) is quoted in "Bivalent booster protects against omicron mutations ahead of winter<https://bit.ly/3zENv4t>" in MyNorthwest.

Dr. Nancy Davidson, professor and head (Medical Oncology) is quoted in "Year in Review: Breast Cancer-Practice-changing therapy for HER2-low breast cancer, potential for some women to skip surgery<https://bit.ly/3zA0nZR>" in Medpage Today.

Dr. Andrew Luks, professor (Pulmonary, Critical Care and Sleep Medicine) is quoted in "Pulse oximeters and their inaccuracies will get FDA scrutiny today. What took so long?<https://bit.ly/3fvuMSc>" in STAT.


Events of interest
Gender Equity Lunch Series: Gender and the Electronic Health Record workload
[cid:image043.jpg at 01D8F06D.F360D2A0]Special guest moderator, Dr. Eve Rittenberg, Harvard Medical Center, will discuss gender and the EHR workload, and her article "Primary Care Physician Gender and Electronic Health Record Workload<https://link.springer.com/article/10.1007/s11606-021-07298-z>" published in the Journal of General Internal Medicine. Eve Rittenberg, MD, is an assistant professor of medicine at Harvard Medical School and a primary care internist at the Fish Center for Women's Health at Brigham and Women's Hospital. Her interests include women's health, trauma-informed care, and health equity. Nov. 8, 12-1pm, via zoom<https://washington.zoom.us/j/93551236119> (meeting ID: 935 5123 6119). Please RSVP<https://forms.office.com/r/Hx5QT3HCxu>.


Weekly Calendar, November 7-11, 2022
Our events calendar is posted on our website<https://medicine.uw.edu/news/trumba-calendar>.


Coming up
Gender Equity reconnection events
The Department of Medicine Gender Equity Council is hosting a series of reconnection events. The purpose of these events is to meet new people and reconnect with colleagues in the department. These events will be held at different sites as a way for people at each location to meet each other and make new connections. Stop by at any time for donuts and coffee - all genders are welcome!


  *   VA, Nov. 15, 12-1pm, Bldg. 1, Rm. 240
  *   HMC, Nov. 16, 1-2pm, 3WH 108
  *   UWMC-ML, Nov. 18, 11am-12pm, RR-110


Current concepts in medication therapy
This CME conference will highlight innovation in drug therapies, review new indications for old medications, and discuss medication side effects and drug interactions. Speakers include DOM faculty from Allergy and Infectious Diseases, Cardiology, Gastroenterology, General Internal Medicine, Metabolism, Endocrinology and Nutrition, and Pulmonary, Critical Care and Sleep Medicine. Dec. 12-13. For more information and to register, please visit the CME website<https://bit.ly/3ER130l>.


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Amy Fields, Editor
amyf at uw.edu<mailto:amyf at uw.edu>


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